| 7,64 % | Avidity Partners Management LP | 6 500 328 | -324 122 | 2023. 12. 31. |
| 7,53 % | Deerfield Management Company, L.P. | 6 401 000 | 3 578 000 | 2023. 12. 31. |
| 6,25 % | Fidelity Management & Research Company LLC | 5 312 297 | 1 135 446 | 2023. 12. 31. |
| 5,57 % | Perceptive Advisors LLC | 4 737 194 | 1 985 799 | 2024. 01. 09. |
| 4,52 % | HealthCap AB | 3 840 702 | 33 455 | 2024. 03. 18. |
| 4,32 % | Johnson & Johnson Innovation-JJDC, Inc. | 3 670 516 | 0 | 2023. 12. 31. |
| 3,83 % | Varian Medical Systems, Inc. | 3 256 972 | 3 256 972 | 2023. 02. 17. |
| 3,67 % | OrbiMed Advisors, LLC | 3 122 770 | 0 | 2023. 12. 31. |
| 3,66 % | CPP Investment Board | 3 116 966 | 0 | 2023. 12. 31. |
| 3,47 % | Adams Street Partners, LLC | 2 947 809 | 0 | 2023. 12. 31. |
| 3,00 % | TPG Capital, L.P. | 2 551 794 | 0 | 2023. 12. 31. |
| 12,77 % | Federated Hermes Global Investment Management Corp. | 10 866 153 | 282 364 | 2023. 12. 31. |
| 1,84 % | Pivotal Bioventure Partners Investment Advisor LLC | 1 560 982 | 0 | 2023. 12. 31. |
| 1,28 % | Sphera Funds Management Ltd. | 1 085 639 | -268 619 | 2023. 12. 31. |
| 1,18 % | Invus Public Equities Advisors, LLC | 1 005 500 | -719 500 | 2023. 12. 31. |
| 1,17 % | William Blair & Company, L.L.C. (Research) | 993 855 | 993 855 | 2023. 12. 31. |
| 0,88 % | Wellington Management Company, LLP | 744 474 | 579 949 | 2023. 12. 31. |
| 0,86 % | 1832 Asset Management L.P. | 734 321 | 0 | 2023. 12. 31. |
| 0,68 % | Eagle Health Investments LP | 579 769 | 0 | 2023. 12. 31. |
| 0,68 % | Millennium Management LLC | 578 102 | -4027 | 2023. 12. 31. |
| 0,59 % | Ikarian Capital LLC | 500 000 | 500 000 | 2023. 12. 31. |
| 0,47 % | Adage Capital Management, L.P. | 400 000 | 400 000 | 2023. 12. 31. |
| 0,45 % | BlackRock Institutional Trust Company, N.A. | 380 187 | 375 975 | 2023. 12. 31. |
| 0,37 % | Marshall Wace LLP | 318 440 | 318 440 | 2023. 12. 31. |
| 0,37 % | Valliant (John Fitzmaurice) | 318 147 | 0 | 2023. 02. 17. |
| 0,37 % | Fred Alger Management, LLC | 311 974 | 311 974 | 2023. 12. 31. |
| 0,35 % | Jennison Associates LLC | 301 020 | 301 020 | 2023. 12. 31. |
| 0,35 % | Point72 Asset Management, L.P. | 293 611 | -35 257 | 2023. 12. 31. |
| 0,33 % | Pier Capital, LLC | 277 111 | 277 111 | 2023. 12. 31. |
| 0,30 % | Walleye Capital LLC | 251 213 | 251 213 | 2023. 12. 31. |
| 0,29 % | Sio Capital Management, LLC | 246 036 | 0 | 2023. 12. 31. |
| 0,26 % | UBS Financial Services, Inc. | 223 092 | 129 783 | 2023. 12. 31. |
| 0,26 % | Woodline Partners LP | 222 462 | 144 427 | 2023. 12. 31. |
| 0,25 % | UBS O'Connor LLC | 213 107 | -61 461 | 2023. 12. 31. |
| 0,18 % | Schonfeld Strategic Advisors LLC | 153 792 | 153 792 | 2023. 12. 31. |
| 0,17 % | Morgan Stanley Smith Barney LLC | 146 328 | -19 732 | 2023. 12. 31. |
| 0,17 % | Privium Fund Management BV | 141 750 | 141 750 | 2023. 12. 31. |
| 0,16 % | Boothbay Fund Management, LLC | 133 550 | 133 550 | 2023. 12. 31. |
| 0,15 % | Two Sigma Investments, LP | 130 433 | 98 333 | 2023. 12. 31. |
| 0,15 % | Atika Capital Management LLC | 130 400 | 130 400 | 2023. 12. 31. |
| 0,15 % | Sofinnova Investments, Inc | 125 299 | 8200 | 2023. 12. 31. |
| 0,15 % | Healthinvest Partners AB | 125 000 | 0 | 2023. 12. 31. |
| 0,13 % | Verition Fund Management LLC | 109 386 | 109 386 | 2023. 12. 31. |
| 0,10 % | Franklin Advisers, Inc. | 89 100 | 89 100 | 2024. 01. 31. |
| 0,10 % | Invesco Advisers, Inc. | 88 130 | 25 451 | 2024. 02. 29. |
| 0,10 % | Jump Financial, LLC | 86 199 | 86 199 | 2023. 12. 31. |
| 0,09 % | Yarbrough Capital, LLC | 76 872 | 0 | 2024. 03. 31. |
| 0,08 % | Cubist Systematic Strategies, LLC | 67 470 | 67 460 | 2023. 12. 31. |
| 0,07 % | Morgan Stanley & Co. LLC | 60 253 | 60 253 | 2023. 12. 31. |
| 0,07 % | BlackRock Investment Management, LLC | 59 154 | -2263 | 2024. 02. 29. |
| 0,07 % | Sectoral Asset Management Inc. | 57 297 | 0 | 2023. 12. 31. |
| 0,07 % | Gannon (Steven R) | 56 400 | 0 | 2023. 02. 17. |
| 0,07 % | abrdn Investments Limited | 56 100 | 56 100 | 2024. 03. 31. |
| 0,06 % | Citadel Advisors LLC | 54 123 | 54 123 | 2023. 12. 31. |
| 0,06 % | Chartwell Investment Partners, LLC | 49 890 | 49 890 | 2023. 12. 31. |
| 0,06 % | Avantis Investors | 48 526 | 48 526 | 2024. 03. 31. |
| 0,06 % | Assenagon Asset Management S.A. | 48 138 | 3536 | 2024. 02. 29. |
| 0,05 % | Superstring Capital Management LP | 45 801 | 45 801 | 2023. 12. 31. |
| 0,05 % | Medical Strategy GmbH | 44 000 | 44 000 | 2023. 12. 31. |
| 0,05 % | Tekla Capital Management LLC_NLE | 43 394 | 0 | 2023. 06. 30. |
| 0,05 % | Khuong (Chau Quang) | 42 093 | 0 | 2023. 02. 17. |
| 0,05 % | Geode Capital Management, L.L.C. | 39 346 | 8478 | 2023. 12. 31. |
| 0,05 % | Burak (Eric) | 38 490 | 0 | 2023. 02. 17. |
| 0,05 % | BlackRock Advisors (UK) Limited | 38 391 | 1843 | 2024. 03. 31. |
| 0,04 % | BlackRock Asset Management Ireland Limited | 35 578 | 35 578 | 2023. 12. 31. |
| 0,04 % | Raymond James Financial Services Advisors, Inc. | 31 145 | 31 145 | 2023. 12. 31. |
| 0,04 % | NEOS Investment Management, LLC | 30 939 | 13 446 | 2023. 12. 31. |
| 0,04 % | RBC Capital Markets Wealth Management | 30 669 | 30 669 | 2023. 12. 31. |
| 0,03 % | Jane Street Capital, L.L.C. | 28 132 | 28 132 | 2023. 12. 31. |
| 0,03 % | Driehaus Capital Management, LLC | 23 270 | 0 | 2024. 02. 29. |
| 0,03 % | XTX Markets LLC | 23 161 | 23 161 | 2023. 12. 31. |
| 0,03 % | The Vanguard Group, Inc. | 23 029 | 23 029 | 2024. 03. 31. |
| 0,03 % | Credit Suisse Funds AG | 21 867 | 21 867 | 2024. 02. 29. |
| 0,03 % | abrdn Inc. | 21 697 | 21 697 | 2023. 12. 31. |
| 0,03 % | Goldman Sachs Asset Management, L.P. | 21 605 | -170 | 2024. 03. 31. |
| 0,02 % | T. Rowe Price Associates, Inc. | 21 100 | 21 100 | 2024. 02. 29. |
| 0,02 % | Raymond James & Associates, Inc. | 20 200 | 20 200 | 2023. 12. 31. |
| 0,02 % | Federated Hermes Equity Management Company of Pennsylvania | 20 000 | -80 000 | 2023. 12. 31. |
| 0,02 % | Group One Trading, L.P. | 19 134 | 19 134 | 2023. 12. 31. |
| 0,02 % | Susquehanna International Group, LLP | 18 465 | 18 465 | 2023. 12. 31. |
| 0,02 % | ProShare Advisors LLC | 17 623 | 12 213 | 2024. 03. 31. |
| 0,02 % | Forefront Analytics, LLC | 16 715 | -16 970 | 2023. 12. 31. |
| 0,02 % | Belvedere Trading, LLC | 16 349 | 16 349 | 2023. 12. 31. |
| 0,02 % | Alpine Associates Management Inc. | 15 700 | 15 700 | 2024. 03. 31. |
| 0,02 % | Goldman Sachs & Company, Inc. | 15 132 | 15 132 | 2023. 12. 31. |
| 0,02 % | Rawat (Mohit) | 12 843 | 12 843 | 2023. 08. 31. |
| 0,01 % | Squarepoint Capital LLP | 12 757 | 12 757 | 2023. 12. 31. |
| 0,01 % | Simplex Trading, LLC | 12 501 | 12 422 | 2023. 12. 31. |
| 0,01 % | Leamon (Christopher Paul Ph.D.) | 11 957 | 11 957 | 2023. 08. 31. |
| 0,01 % | Envestnet Asset Management, Inc. | 11 454 | 11 454 | 2023. 12. 31. |
| 0,01 % | Crowley (John Joseph CPA) | 10 410 | 0 | 2023. 02. 17. |
| 0,01 % | Vanguard Investments Australia Ltd. | 10 380 | 10 380 | 2024. 02. 29. |
| 0,01 % | Renaissance Technologies LLC | 10 000 | 10 000 | 2023. 12. 31. |
| 0,01 % | AlphaSimplex Group, LLC | 9590 | 9590 | 2024. 02. 29. |
| 0,01 % | Preston (Heather Elizabeth) | 8823 | 0 | 2023. 02. 17. |
| 0,01 % | Mercer Global Investments Management Ltd | 8600 | 8600 | 2024. 03. 31. |
| 0,01 % | Cutler Group, LP | 8600 | 7500 | 2024. 03. 31. |
| 0,01 % | State Street Global Advisors Ireland Limited | 8500 | 8500 | 2024. 03. 31. |
| 0,01 % | American Century Investment Management, Inc. | 8399 | 8399 | 2024. 03. 31. |
| 0,01 % | China Universal Asset Management Co., Ltd. | 8376 | 8376 | 2023. 12. 31. |
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